Anti-ganglioside antibodies induced in chickens by an alum-adsorbed anti-idiotype antibody targeting NeuGcGM3

Anti-ganglioside antibodies induced in chickens by an alum-adsorbed anti-idiotype antibody targeting NeuGcGM3

Racotumomab is a murine anti-idiotype cancer vaccine targeting NeuGcGM3 on melanoma, breast, and lung cancer. In order to characterize the immunogenicity of alum-adsorbed racotumomab in a non-clinical setting, Leghorn chickens were immunized in dose levels ranging from 25 μg to 1600 μg. Racotumomab was administered subcutaneously in the birds' neck with three identical boosters and serum sample...

Detection of Anti-Ganglioside Antibodies in Guillain-Barre Syndrome

Immunized with an Anti-Idiotype Antibody Non-Small Cell Lung Cancer Patients against NeuGcGM3 Ganglioside Elicited in Characterization of the Antibody Response

Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody.

1E10 mAb is an anti-Id murine mAb (Ab2 mAb) specific for an Ab1 mAb that reacts with NeuGc-containing gangliosides, sulfatides, and Ags expressed in some human tumors. In preclinical studies, this Ab2 Ab was able to mimic NeuGc-containing gangliosides only in animals lacking expression of these Ags in normal tissues. In this study, we report on the immune responses elicited in 20 non-small cell...

Anti - Anti - Idiotype Effect on Antibody Response

It has recently been shown that an idiotypic determinant(s) (460-Id) 1 found on the 2,4-dinitrophenyl (DNP) and 2,4,6-trinitrophenyl (TNP)-binding myeloma protein, MOPC-460, is expressed on some anti-TNP antibodies produced by BALB/c mice after immunization with certain thymus-independent (TI) (1) and thymus-dependent (2) TNP antigens. In vitro studies indicate that the 460-Id-bearing component...